Energy Landscape Reveals That the Budding Yeast Cell Cycle Is a Robust and Adaptive Multi-stage Process
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منابع مشابه
Energy Landscape Reveals That the Budding Yeast Cell Cycle Is a Robust and Adaptive Multi-stage Process
Quantitatively understanding the robustness, adaptivity and efficiency of cell cycle dynamics under the influence of noise is a fundamental but difficult question to answer for most eukaryotic organisms. Using a simplified budding yeast cell cycle model perturbed by intrinsic noise, we systematically explore these issues from an energy landscape point of view by constructing an energy landscape...
متن کاملText S1 Energy landscape reveals that the budding yeast cell cycle is a robust and adaptive multi-stage process Supporting Information
I. The three-node Budding Yeast Cell Cycle Model II. Stochastic Model III. Large Deviation Theory and the Hamiltonian IV. Overview of the Construction of the Landscape V. Introduction of the gMAM V-A. The Outer Loop V-B. Evaluating the Action V-C. The Inner Loop VI. Construction of the Quasi-potential energy landscape VI-A. Landscape with One Stable State VI-B. Landscape with Two Stable States ...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2015
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1004156